发明名称 |
METHODS OF TREATMENT WITH COMPOUNDS HAVING RAR ALPHA RECEPTOR SPECIFIC OR SELECTIVE ACTIVITY |
摘要 |
Retinoid compounds which act specifically or selectively on RARalpha receptor subtypes in preference over RARbeta and RARGAMMA receptor subtypes, possess desirable pharmaceutical properties associated with retinoids, and are particularly suitable for treatment of tumors, such as acute monocytic leukemia, cervical carcinoma, myeloma, ovarian carcinomas and head and neck carcinomas, without having one or more undesirable side effects of retinoids, such as inducement of weight loss, mucocutaneous toxicity, skin irritation and teratogenecity. |
申请公布号 |
WO9724116(A3) |
申请公布日期 |
1997.11.13 |
申请号 |
WO1996US20511 |
申请日期 |
1996.12.16 |
申请人 |
ALLERGAN |
发明人 |
TENG, MIN;DUONG, TIEN, T.;CHANDRARATNA, ROSHANTHA, A. |
分类号 |
A61K45/00;A61K31/00;A61K31/19;A61K31/20;A61K31/203;A61K31/215;A61K31/245;A61K31/27;A61K31/35;A61K31/352;A61K31/353;A61K31/38;A61K31/44;A61K31/495;A61P3/00;A61P3/06;A61P5/00;A61P5/06;A61P5/10;A61P9/00;A61P17/00;A61P17/02;A61P17/06;A61P17/14;A61P25/00;A61P27/00;A61P27/02;A61P29/00;A61P31/00;A61P31/12;A61P35/00;A61P35/02;A61P37/00;G01N25/48 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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