Variant activin receptor polypeptides, alone or in combination with chemotherapy, and uses thereof

摘要

Disclosed is a pharmaceutical composition comprising (i) an isolated protein comprising a variant activin IIB receptor polypeptide (vActRIIB), wherein vActRIIB comprises a polypeptide sequence having at least 95% identity to the amino acid sequence set forth at amino acids 25 through 134 of the sequence set forth in SEQ ID NO:18, wherein the polypeptide comprises an amino acid substitution at position 28, and wherein the polypeptide is capable of binding myostatin, activin A, or GDF-11, and (ii) a chemotherapeutic agent. Also disclosed is the use of such compositions in the manufacture of a medicament for treating cancer.