| 发明名称 |
NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS |
| 摘要 |
A skin treatment composition for topical application comprises: at least one thyroid hormone compound or thyroid hormone-like compound, wherein said thyroid hormone compound or thyroid hormone-like compound is a chemical entity which binds to TR alpha or TR beta with a dissociation constant, Kd, lower than 1 mu M, wherein <DF>Kd = ÄRÜ • ÄLÜ / ÄRLÜ, </DF> wherein ÄRÜ is the concentration of receptor, ÄLÜ is the concentration of ligand and ÄRLÜ is the concentration of the receptor-ligand complex; at least one ingredient selected from vitamin D, glucocorticoids, retinoids and retinoic acid receptor binding compounds, or analogues thereof; and a pharmacologically acceptable base. |
| 申请公布号 |
WO9640048(A3) |
申请公布日期 |
1997.11.13 |
| 申请号 |
WO1996US09975 |
申请日期 |
1996.06.07 |
| 申请人 |
KARO BIO AB;LAVIN, THOMAS, N.;VAHLQUIST, ANDERS, B. |
发明人 |
LAVIN, THOMAS, N.;VAHLQUIST, ANDERS, B. |
| 分类号 |
C07D237/14;A61K8/14;A61K8/30;A61K8/34;A61K8/44;A61K8/49;A61K8/64;A61K8/65;A61K8/66;A61K31/055;A61K31/137;A61K31/19;A61K31/192;A61K31/195;A61K31/34;A61K31/341;A61K31/343;A61K31/425;A61K31/426;A61K31/44;A61K31/505;A61K31/53;A61K38/06;A61K38/22;A61K45/00;A61P3/02;A61P5/12;A61P17/00;A61Q19/00;A61Q19/06;A61Q19/08;C07D213/30;C07D213/61;C07D213/64;C07D277/20;C07D277/34;C07D307/80;C07D307/83 |
主分类号 |
C07D237/14 |
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