NOVEL MONOCLONAL ANTIBODY HAVING INHIBITORY EFFECT ON TYPE II PHOSPHOLIPASE A2 AND PROTEIN CONTAINING A PART OF THE SAME.

摘要

A novel monoclonal antibody inhibiting the activity of type II phospholipase A2. The antibody inhibits the activity of human type II phospholipase A2 and those of ape type II phospholipase A2 and/or mouse type II phospholipase A2, which makes it not only clinically useful but also usable as such in preclinical tests with the use of ape or mouse. The antibody, which has a completely novel characteristic of releasing type II phospholipase A2 bound to cell membrane, seems to strongly inhibit the type II phospholipase A2 activity via a novel mechanism. A protein containing the monoclonal antibody or a part of the same and being usable as a remedy for heart infarction, brain infarction, etc. in which type II phospholipase A2 participates.