发明名称 Process for the preparation of 3-aryloxy-3-phenyl-propylamines
摘要 Compounds of the annexed formula I <IMAGE> are prepared in which every R1 and R2 independently of one another represents hydrogen or methyl, R3 and R4 represent halogen, -CF3, C2-C4-alkyl, C1-C3-alkoxy or C3-C4-alkenyl and n and m represent 0, 1 or 2, but where the sum of n and m is not 0 if both R1 denote CH3 and both R2 denote H, and their acid addition salts with pharmaceutically acceptable acids. To do this, the appropriate optionally substituted 3-chloro-1-phenoxy-1-phenylpropane is reacted with ammonia or an amine of the formula NHR1R1 and the compound obtained is optionally converted into its acid addition salt. The compounds of the formula I can be used as psychotropic agents, in particular as antidepressants.
申请公布号 CH609331(A5) 申请公布日期 1979.02.28
申请号 CH19780002228 申请日期 1975.01.07
申请人 LILLY, ELI, AND CO. 发明人 BRYAN BARNET MOLLOY;KLAUS KURT SCHMIEGEL
分类号 A61K31/135;(IPC1-7):C07C93/00 主分类号 A61K31/135
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