| 摘要 |
PURPOSE:To obtain the compound suppressing HIV protease related to manifestation of proliferation and character of AIDS virus by hydrogenating a diamino- diphenyl-hexen-one derivative in the presence of a transition metal-containing catalyst. CONSTITUTION:A (2S)-2,5-diamino-1,6-diphenyl-4-hexen-3-one derivative of the formula I [R<1> is a (halogen-substituted) lower alkylcarbonyl, an arylcarbonyl or a lower alkoxycarbonyl; R<2> and R<3> each is an (alkoxy-substituted) aryll is hydrogenated in the presence of a transition metal-containing catalyst (preferably an activated metal such as ruthenium, rhodium, palladium or indium supported on a carrier selected from active carbon, silica, alumina or silica- alumina) to give the objective compound of the formula II. |
