发明名称 |
CHEMISCHE PROZESSE ZUR HERSTELLUNG VON 1,2-EPOXY-1,2,3,4-TETRAHYDRNAPHTALEN |
摘要 |
PCT No. PCT/GB94/00307 Sec. 371 Date Aug. 25, 1995 Sec. 102(e) Date Aug. 25, 1995 PCT Filed Feb. 26, 1994 PCT Pub. No. WO94/19338 PCT Pub. Date Sep. 1, 1994Described herein is a process for the preparation of (1S,2R)-1,2-epoxy-1,2,3,4-tetrahydronaphthalene having the Formula (I): <IMAGE> Formula (I) which comprises the steps of (a) hydrogenating the compound of Formula (II) to form cis-(1R, 2S)-1,2-dihydroxy-1,2,3,4-tetrahydronaphthalene having the Formula (V): <IMAGE> (b) reacting the dihydroxy compound of Formula (V) with a sulphonyl halide of formula R1SO2Z wherein R1 is methyl, ethyl, trifluoromethyl, phenyl or p-tolyl, and Z is fluorine, chlorine, bromine or iodine to give a bis-sulphonyl ester of formula (X): <IMAGE> and (c) treating the bis-sulphonyl ester (X) with an alkali metal carbonate or alkali metal hydroxide to give the compound of Formula (I). |
申请公布号 |
DE69403637(T2) |
申请公布日期 |
1997.09.18 |
申请号 |
DE1994603637T |
申请日期 |
1994.02.16 |
申请人 |
ZENECA LTD., LONDON, GB |
发明人 |
BLACKER, ANDREW, JOHN 2 THE CRESCENT, LEEDS LS17 0DD, GB;BROWN, STEPHEN, MARTIN 4 DEARNFIELD, HUDDERSFIELD HD8 8NX, GB;BOYD, DEREK, RAYMOND 91 MARYVILLE PARK, BELFAST BT9 6LQ, GB;SHELDRAKE, GARY, NEIL 16 TURNSHAWS CLOSE, HUDDERSFIELD HD8 0TQ, GB |
分类号 |
C07C67/00;C07C69/013;C07C69/63;C07C69/773;C07C203/08;C07C203/10;C07C309/65;C07C309/66;C07C309/72;C07D301/02;C07D303/04;C07D303/14;C07D317/70;C12P7/22;(IPC1-7):C07D301/02;C07D303/48;C07D317/44;C07C309/63;C07C309/64;C07C309/73 |
主分类号 |
C07C67/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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