发明名称 |
METHOD AND APPARATUS FOR SYNTHESIS OF ARRAYS OF DNA PROBES |
摘要 |
The synthesis of arrays of DNA probe sequences, polypeptides and the like is carried out using a patterning process on an active surface of a substrate (12). An image is projected onto the active surface (15) utilizing an image former (11) that includes a light source that provides light to a micromirror device (35) comprising an array of electronically addressable micromirrors (36). The substrate (12) is activated in a defined pattern and bases are coupled at the activated sites, with further repeats until the elements of a two-dimensional array on the substrate have an appropriate base bound thereto. The micromirror array (35) can be controlled in conjunction with a DNA synthesizer to control the sequencing of images presented by the micromirror array (35) in coordination with the reagents provided to the substrate (12).
|
申请公布号 |
WO9942813(A1) |
申请公布日期 |
1999.08.26 |
申请号 |
WO1999US03807 |
申请日期 |
1999.02.22 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
CERRINA, FRANCESCO;SUSSMAN, MICHAEL, R.;BLATTNER, FREDERICK, R.;SINGH-GASSON, SANGEET;GREEN, ROLAND |
分类号 |
G01N33/53;B01J19/00;C07B61/00;C07H21/00;C08K3/00;C12M1/34;C12Q1/68;C40B40/06;C40B60/14;G01N21/05;G01N21/17;G01N37/00;G02B26/08;G03F7/20;(IPC1-7):G01N21/00;G01N1/00;G01N21/01;G01N33/543 |
主分类号 |
G01N33/53 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|