| 摘要 |
<p>Catheter system (9) with centrally located drug delivery catheter (20) is adapted to be implanted at a depth within the left ventricular apex (15) of the heart (10). Hollow penetrating structure (30) penetrates the heart muscle from the endocardial side. The delivery catheter is navigated into the endorcardial space of the left ventricle (510), and secured in place with penetrating structure (30). A small dose of therapeutic agent, molecules (35), is injected into the myocardium, and the penetrating structure (30) is withdrawn. The molecules (35) of the therapeutic agent are taken up by the lymphatic system, entering into vessels (501, 502), transported upwardly; also migrate out of the lymphatic system, and into the coronary artery (505).</p> |
