发明名称 OIL-IN-WATER EMULSION EXHIBITING A PROTECTIVE ACTION AGAINST DAMAGES TO HUMAN ORGANS RESULTING FROM PEROXIDATION, AND THE PRODUCTION AND USE THEREOF
摘要 The invention relates to an oil-in-water emulsion comprising, as an active ingredient, alpha -tocopherol or the stereoisomers thereof and comprising, as an emulsifier, phospholipids. The inventive emulsion is used in order to attain a protective action against damages to human organs resulting from peroxidation. The emulsion contains a alpha -tocopherol content, with regard to action, of 1.48 g/l to 30 g/l RRR-g(a)-tocopherol, 0-25 g/l of an oil which is compatible with I.V. administration, and 0.25 g/l to 3 g/l of a phospholipid. The emulsion is preferably administered as an infusion and is especially used to reduce damages resulting from peroxidation due to ischaemia and/or reperfusion and, among other things, during an organ transplantation.
申请公布号 WO0037108(A1) 申请公布日期 2000.06.29
申请号 WO1999EP10106 申请日期 1999.12.18
申请人 FRESENIUS KABI AUSTRIA GMBH;EGGENREICH, UDO;FEICHTINGER, NORBERT;HOFER, GERALD;SCHAUPP, KARIN;SOMMERMEYER, KLAUS;WURM, ANNELIESE;NAGEL, ECKHARD;MEYER ZU VILSENDORF, ANDREAS 发明人 EGGENREICH, UDO;FEICHTINGER, NORBERT;HOFER, GERALD;SCHAUPP, KARIN;SOMMERMEYER, KLAUS;WURM, ANNELIESE;NAGEL, ECKHARD;MEYER ZU VILSENDORF, ANDREAS
分类号 A61K9/00;A61K9/107;A61K31/355;A61K31/375;A61K47/10;A61K47/24;A61K47/44;A61P39/06;(IPC1-7):A61K47/10 主分类号 A61K9/00
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