THE POLYPEPTIDE DREAM, USED AS Ca<2+>IONS-DEPENDENT TRANSCRIPTIONAL REGULATOR AND ITS GENE CODING THEREFOR

摘要

The DREAM suppression of the genic expression depending on DRE (c-jun and c-fos between two forms of DREAM (EFmutDREAM and LVmutDREAM) escape from the blocking by Ca2+ and by others) is regulated by Ca2+ and by the protein alpha CREM. Mutant forms alpha CREM respectively enable to define new strategies for the therapeutic control of pathologic process of oncologic type, troubles of apprenticeship, etc. On the other hand, DREAM is a target protein for the identification of new therapeutic compounds. Furthermore, the mutant forms in the regions of EF-hands of DREAM (EFmutDREAM) block the activities of CRE-dependent proteins and can be used in the regulation of the expression of these genes. CREB and CREM are involved in the final activation of a multiplicity of genes.