| 摘要 |
By isolating a cDNA encoding a novel protein originating in human brain, a novel ADAMTS family protein, which is found out as belonging to the ADAMTS family based on the analysis of its homology with known sequences and in which a reprolysin-type ZN-metalloprotease domain, a disintegrin-like domain and a TSP1 (thrombospondin type 1) domain are conserved, is obtained. This protein is characterized by high-expression in ovaries, changes in expression dose depending on the sexual cycle, a decrease in content in tumor cells and location of the gene on the 5P-syndrome deletion site on chromosome. By taking advantage of these characteristics, the above-described cDNA; the above-described protein and a polypeptide or a peptide derived therefrom ; an antibody against the protein; a method of screening an inhibitor, an antagonist or a promoter of the effect of the protein; compounds thus screened; etc. are provided. Moreover, medicinal compositions and diagnostic and therapeutic methods with the use of the same are provided. |
