发明名称 |
METHODS, COMPOSITIONS, AND GROWTH AND DIFFERENTIATION FACTORS FOR INSULIN-PRODUCING CELLS |
摘要 |
<p>A method of converting differentiated non-hormone producing pancreatic cells into differentiated hormone producing cells is disclosed. The method comprises two steps: first, culturing cells under conditions which convert differentiated non-hormone producing cells into stem cells; and second, culturing stem cells under conditions which provide for differentiating stem cells into hormone-producing cells. The invention defines growth and differentiation factors that are presented to the stem cells to result in their differentiation into hormone-producing cells, especially insulin-producing cells. The invention provides a new source of large quantities of hormone producing cells such as insulin-producing cells that are not currently available for therapeutic uses such as the treatment of diabetes.</p> |
申请公布号 |
EP1507552(A2) |
申请公布日期 |
2005.02.23 |
申请号 |
EP20030731406 |
申请日期 |
2003.05.28 |
申请人 |
NOVOCELL, INC.;BECTON DICKINSON AND COMPANY |
发明人 |
SCHARP, DAVID;HEIDARAN, MOHAMMAD, A.;HAALAND, PERRY, D.;MCINTYRE, CATHERINE, ANNE;PRESNELL, SHARON, C. |
分类号 |
A61K35/12;C12N5/071;(IPC1-7):A61K38/16;C12N5/00;A61K38/19;C07K5/00;A01N1/02;C07K14/00 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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