摘要 |
<p>The invention relates to a method for producing alginic acid conjugates by the interaction thereof with amine-containing compounds in the presence of a condensing 1-ethyl-3[-(diethylamino)propyl]carbodiimide (EDC) reagent in an aqueous medium at a room temperature and pH ranging from 4.7 to 4.8. The amine-containing compounds are embodied in the form of n- and o-aminophenols, 5- and 4-amino-salicylic, anthronic and n-amino-benzoic acids, an n-amino-benzoic acid diethyl ester (anaesthesine), an n-amino-benzoic acid ß-diethyl-aminoethyl ester (novocain), 1-phenyl-2,3-diethyl-4-aminopyrazolone-5-(4-aminoantipyrine), an isonicotinic acid hydrazide (isoniazide), a 2-amino-ethanesulphonic acid (taurin), 7-amino-cephalosporin acid and sulphanilamide preparations such as n-amino-benzene-sulphanilamide (streptocide), n-amino-benzene-sulfacetamide (sulphacile-sodium) etc. The thus obtainable alginic acid conjugates can be used in medicine and pharmacology.</p> |
申请人 |
INSTITUT NEFTEKHIMII I KATALIZA RAN;PONEDELKINA, IRINA YURIEVNA;ODINOKOV, VIKTOR NIKOLAEVICH;LUKINA, ELENA SERGEEVNA;VALIEVA, LILIA VALERIEVNA;DZHEMILEV, USEIN MEMETOVICH;BASHKATOV, SERGEI ALEXANDROVICH;SUFIYAROVA, ROZA SHAIKHALNUROVNA;PARFENOVA, TAMARA ILIINICHNA;SERIK, EVGENY MIKHAILOVICH |
发明人 |
PONEDELKINA, IRINA YURIEVNA;ODINOKOV, VIKTOR NIKOLAEVICH;LUKINA, ELENA SERGEEVNA;VALIEVA, LILIA VALERIEVNA;DZHEMILEV, USEIN MEMETOVICH;BASHKATOV, SERGEI ALEXANDROVICH;SUFIYAROVA, ROZA SHAIKHALNUROVNA;PARFENOVA, TAMARA ILIINICHNA;SERIK, EVGENY MIKHAILOVICH |