发明名称 |
Matrices for drug delivery and methods for making and using the same |
摘要 |
In one aspect, biocompatible matrices such as sol-gels encapsulating a reaction center may be administered to a subject for conversion of prodrugs into biologically active agents. In certain embodiments, the biocompatible matrices of the present invention are sol-gels. In one embodiment, the enzyme <SMALLCAPS>L</SMALLCAPS>-amino acid decarboxylase is encapsulated and implanted in the brain to convert <SMALLCAPS>L</SMALLCAPS>-dopa to dopamine for treatment of Parkinson's disease.
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申请公布号 |
US2007098807(A1) |
申请公布日期 |
2007.05.03 |
申请号 |
US20060434488 |
申请日期 |
2006.05.15 |
申请人 |
MOLECULAR INSIGHT PHARMACEUTICALS, INC. |
发明人 |
BABICH JOHN W.;ZUBIETA JON;BONAVIA GRANT |
分类号 |
A61K38/48;A61K47/04;A61K9/16;A61K9/50;A61K31/198;A61K39/395;A61K47/48;A61P25/16;C12Q1/00;G01N33/543;G01N33/552 |
主分类号 |
A61K38/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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