发明名称 |
Compositions and methods to modulate an immune response to an immunogenic therapeutic agent |
摘要 |
Methods and compositions for modulating an immune response to an immunogenic therapeutic agent are disclosed. One of the disclosed methods comprises administering an effective amount of CTLA-4 to decrease the incidence of an immune reaction in conjunction with the administration of a potentially immunogenic substance. Another method contemplates tolerizing a subject to a therapeutic molecule that is or is capable of being immunogenic by the administration of CTLA-4. Various embodiments of CTLA-4 are also disclosed. |
申请公布号 |
US7579316(B2) |
申请公布日期 |
2009.08.25 |
申请号 |
US20050057923 |
申请日期 |
2005.02.14 |
申请人 |
AMGEN INC. |
发明人 |
KHARE SANJAY D.;FEIGE ULRICH |
分类号 |
A61K38/16;A61K;A61K38/17;A61K38/19;A61K39/395;C07K14/705;C07K16/46 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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