发明名称 |
MULTIMERIC PROTECTED FLUORESCENT REAGENTS |
摘要 |
Multimeric protected fluorescent reagents and their methods of synthesis are provided. The reagents are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The reagents contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements. The reagents also contain coupling elements connect monomeric compounds into multimeric forms, thereby increasing brightness. |
申请公布号 |
WO2016126941(A1) |
申请公布日期 |
2016.08.11 |
申请号 |
WO2016US16564 |
申请日期 |
2016.02.04 |
申请人 |
PACIFIC BIOSCIENCES OF CALIFORNIA, INC. |
发明人 |
ZHENG, FRANK;HANES, JEREMIAH;SHEN, GENE;BROGLEY, LOUIS;YUE, STEPHEN;LAPIN, YURI;LYLE, JOHN;OSUNA, HONEY;FEDOROV, ANDREI;SEBO, LUBOMIR |
分类号 |
A61K38/00;A61K38/02;C07K14/435;C12Q1/68;G01N33/58 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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