发明名称 |
Method for synthesis of desferrioxamine B, analogs and homologs thereof |
摘要 |
Synthesis of desferrioxamine B and analogs and homologs thereof beginning with O-protected, N-protected hydroxylamine, which is N-alkylated to produce a protected N-4-cyanoalkylhydroxylamine which is acylated with a suitable anhydride. The resulting half-acid amide is subjected to a series of high yield condensations and reductions which provide desferrioxamine B in high overall yield. Alternatively, polyether analogs of desferrioxamine B can be prepared by reacting an activated polyether with the O-protected, N-protected hydroxylamine and subjecting the resulting product to a series of similar steps.
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申请公布号 |
US5254724(A) |
申请公布日期 |
1993.10.19 |
申请号 |
US19910784949 |
申请日期 |
1991.10.30 |
申请人 |
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. |
发明人 |
BERGERON, JR., RAYMOND J. |
分类号 |
C07C259/06;(IPC1-7):C07C259/06 |
主分类号 |
C07C259/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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