METHOD OF CAUSING SELECTIVE IMMUNOSUPPRESSION USING HL-60-RELATED LECTINS

摘要

The invention provides methods of treating a neoplastic disease characterized by proliferation of lymphocytes by administering pharmaceutical compositions comprising a soluble lectin having a molecular weight of about 14 kilodaltons. In addition, methods of treating a lectin-producing tumor by administering an effective amount of an antibody that specifically binds the lectin, lectin antagonists, inhibitory saccharides, or glycosylation inhibitors in order to prevent lectin-induced apoptosis of tumor-infiltrating T cells.