发明名称 |
Human phosphodiesterase type IVC, and its production and use |
摘要 |
Recombinant human phosphodiesterase type IVC is described, and DNA coding for it. Particular conformers of the enzyme are identified, including a R- and S-rolipram stereoselective conformer which is obtainable by expression of human phosphodiesterase type IVC DNA in mammalian or insect cells. The recombinant enzyme may be used in a screen to select a compound capable of modulating the action of the enzyme, or as an immunogen to generate an antibody.
|
申请公布号 |
US5851784(A) |
申请公布日期 |
1998.12.22 |
申请号 |
US19950577492 |
申请日期 |
1995.12.22 |
申请人 |
CELLTECH THERAPEUTICS, LIMITED |
发明人 |
OWENS, RAYMOND JOHN;PERRY, MARTIN JOHN;LUMB, SIMON MARK |
分类号 |
C12N15/09;A61K31/70;A61K38/46;A61P11/00;A61P29/00;C07H21/04;C07K16/40;C12N9/16;C12N15/55;(IPC1-7):C12Q1/44 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|