发明名称 |
Methods and means for the treatment of disorders associated with cellular senescence |
摘要 |
This invention relates to mechanisms of cellular senescence and, in particular, to the role of DNA repair and DNA damage checkpoint pathways in the induction and maintenance of the senescent state. Methods and means of inducing cell cycle progression in senescent cells by inhibiting DNA damage checkpoint pathways are provided herein. These methods and means provide agents and therapies for the treatment of senescent associated disorders.
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申请公布号 |
US2007099186(A1) |
申请公布日期 |
2007.05.03 |
申请号 |
US20040554878 |
申请日期 |
2004.04.21 |
申请人 |
D ADDA DI FAGAGNA FABRIZIO;REAPER PHILIP M;JACKSON STEPHEN |
发明人 |
D'ADDA DI FAGAGNA FABRIZIO;REAPER PHILIP M.;JACKSON STEPHEN |
分类号 |
C12Q1/68;A61K31/397;A61K31/4025;A61K31/4433;A61K31/4436;A61K31/452;A61K31/453;A61K31/55;C12Q1/48;G01N33/567;G01N33/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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