High dose ibandronate formulation

摘要

Disclosed is a pharmaceutical composition for the treatment of bone diseases and disturbance of calcium metabolism, containing a disintegrant, a filler material and as active substance up to 250 mg of ibandronic acid or physiologically safe salts thereof for oral application, wherein the composition has been prepared by a granulation process including the step of adding the disintegrant in the granulate together with the active substance and with a part of the filler material.