发明名称 Acylaminothiazole derivatives, their preparation and therapeutic use
摘要 The invention concerns a compound of general formula (I), wherein: X represents an oxygen or sulphur atom; R<SUB>1 </SUB>represents, independently of each other when n=2 or 3, a halogen atom, a hydroxy, a C<SUB>1</SUB>-C<SUB>3 </SUB>alkyl, a C<SUB>1</SUB>-C<SUB>3 </SUB>alkoxy, a trifluoromethyl, a trifluoromethyloxy or a methylenedioxy; R<SUB>2 </SUB>represents a C<SUB>1</SUB>-C<SUB>6 </SUB>alkyl group optionally substituted, a C<SUB>3</SUB>-C<SUB>7 </SUB>cycloalkyl, piperidinyl or phenyl group, the C<SUB>3</SUB>-C<SUB>7 </SUB>cycloalkyl, piperidinyl or phenyl groups being optionally substituted; R<SUB>3 </SUB>represents a hydrogen atom or a C<SUB>1</SUB>-C<SUB>6 </SUB>alkyl group optionally substituted; R<SUB>4 </SUB>represents a hydrogen atom or a C<SUB>1</SUB>-C4 alkyl group; and R<SUB>5 </SUB>and R<SUB>5'</SUB> represent, independently of each other, a hydrogen atom, a hydroxy, a halogen atom, a C<SUB>1</SUB>-C<SUB>3 </SUB>alkyl group, or R<SUB>5 </SUB>and R<SUB>5'</SUB> form together an oxo group; R<SUB>6 </SUB>represents a hydrogen atom, a halogen atom, a C<SUB>1</SUB>-C<SUB>3 </SUB>alkyl, a C<SUB>1</SUB>-C<SUB>3 </SUB>alkoxy, a trifluoromethyl, or a trifluoromethoxy; in the form of a base, addition to an acid, hydrate or solvate. The invention is applicable in therapy
申请公布号 US7288659(B2) 申请公布日期 2007.10.30
申请号 US20040485837 申请日期 2004.02.04
申请人 SANOFI-AVENTIS 发明人 DE COINTET PAUL;DESPEYROUX PIERRE;FREHEL DANIEL;GUENET CHANTAL;HECKEL CORINNE;MAFFRAND JEAN-PIERRE;PRUSS REBECCA
分类号 C07D277/20;C07D277/46;A61K31/426;A61P9/10;A61P25/16;A61P25/28;C07D277/40;C07D277/42;C07D277/48;C07D417/12 主分类号 C07D277/20
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