BIOMARKERS FOR HUMAN PAPILLOMAVIROUS-ASSOCIATED CANCERS

摘要

Cervical cancer ceils and HPV" head and neck cancer cells express three testis-specific genes not normally expressed m somatic cells; testicular cell adhesion molecule 1 (TCAM1). synaptosomal complex protein 2 (SYCP2) and stromal antigen 3 (STAG3). Among the three markers. "TCAM1 and SYCP2 arc early detection markers. Various methods for identifying a human or non-human animal as a carsdidaie for further examination for cervical cancer, preneoplastic-lesion ibr cervical cancer, head and neck cancer or preneoplastic lesion for head and neck cancer are disclosed. Methods of detecting said cancers and preneoplastic lesions, methods of screening for drugs for treating said cancers and preneoplastic lesions, methods for-monitoring the effectiveness of a treatment for said cancers, and methods of treating said cancers are also disclosed. Further disclosed are kits that can be used to practice the above methods.