| 摘要 |
<p>Provided is a kind of modified recombinant human endostatin that has the structure of CH3O-(CH2CH2O)m-CH2CH2CH2-NaH-Endostar, wherein the average molecular weight of CH3O-(CH2CH2O)m-CH2CH2CH2 is 20-40kD. The modified recombinant human endostatin enhances the stability in vivo, improves blood drug concentration, prolongs half-life, markedly increases the activity of inhibiting the endothelial cells proliferation, thus reduces drug dosage and decreases administration frequency. Its application for preparing anti-tumor pharmaceutical compositions is also provided.</p> |
| 申请人 |
JIANGSU SIMCERE PHARMACEUTICAL R & D CO., LTD.;CHINA PHARMACEUTICAL UNIVERSITY;SHANDONG XIANSHENG MAIDEJIN BIOLOGICAL PHARMACEUTICAL CO., LTD.;YAO, WENBING;TIAN, HONG;XU, XIANGYANG;LI, HAIRUI;TONG, YUE;GAO, XIANGDONG |
发明人 |
YAO, WENBING;TIAN, HONG;XU, XIANGYANG;LI, HAIRUI;TONG, YUE;GAO, XIANGDONG |
