1,2-SUBSTITUTED CYCLOALKANE DERIVATIVES AS THROMBINE INHIBITORS, A PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF IN PHARMACEUTICAL FORMULATIONS

摘要

Compounds containing a 1,2-disubstituted cycloalkane or cycloalkene ring with inhibitory activity on serinoproteases of general formula (I) wherein A is selected from the (CH2)n group with n = -3, CH=CH and Ar, L, X, Q, Y, W are as defined; processes for the preparation thereof, pharmaceutical compositions containing them and the use thereof as therapeutical agents.