| 摘要 |
1,201,404. Ascorbic acid - 3 - phosphate. TAKEDA YAKUHIN KOGO K.K. 30 Oct., 1968 [31 Oct., 1967], No. 51386/68. Heading C2V. Ascorbic acid-3-phosphate is obtained by phosphorylating ascorbic acid with a phosphoric acid halide in the presence of a base and in a solvent whose dielectric constant at 20‹ C. and 10<SP>4</SP> cycles/sec. is not less than 23. The solvent may be one or more of the compounds acetonitrile, methanol, glycerine, - nitrobenzene, dimethylformamide; trimethyl phosphate, N- methylacetamide, water or -formamide. The phosphoric acid halide may be phosphorochloridic acid, phosphorodichloridic acid, phosphorofluoridic acid, phosphorobromidic acid, phosphorus oxychloride, phosphorus oxybromide, phosphorus pentachloride or pyrophosphoryl tetrachloride. The base may be an alkali metal or alkaline earth metal hydroxide or carbonate or an aliphatic amine or a cyclic amine. The hydroxyl groups at the 5 and 6 positions of the ascorbic acid may be masked by forming a condensation product with a ketone having three to ten carbon atoms. When the reaction product is an ascorbic acid-3- halophosphate or is masked in the 5 and 6 positions, it is hydrolysed to obtain the ascorbic acid-3-phosphate. Examples are given. |
