Use of prostaglandin analogues to treat cytodamage

摘要

Prostaglandin analogue of the formula: <IMAGE> (VA) or <IMAGE> (VB) wherein R1 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atom(s), R2 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 6 carbon atom(s), the symbols---X-Y-Z- in formula VB represent one of the groups: <IMAGE> (i) <IMAGE> (ii) <IMAGE> (iii) <IMAGE> (iv) <IMAGE> (v) wherein in formulae (ii) and (iv), the configuration on C6 is S- or R-configuration or a mixture thereof and in formulae (iii) and (v) the double bond between C5 and C6 is in E- or Z-configuration or a mixture thereof) and n represents an integer of from 3 to 5 non-toxic salts thereof when R1 represents a hydrogen atom and cyclodextrin clathrates thereof are useful in the prevention or treatment of cytodamage associated with many diseases, especially liver damage.