发明名称 CONJUGATES USEFUL IN THE TREATMENT OF PROSTATE CANCER
摘要 Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).
申请公布号 WO9818493(A2) 申请公布日期 1998.05.07
申请号 WO1997US19225 申请日期 1997.10.27
申请人 MERCK & CO., INC.;GARSKY, VICTOR, M.;FENG, DONG-MEI;DEFEO-JONES, DEBORAH 发明人 GARSKY, VICTOR, M.;FENG, DONG-MEI;DEFEO-JONES, DEBORAH
分类号 A61K31/337;A61K31/407;A61K31/475;A61K31/513;A61K31/517;A61K31/675;A61K31/704;A61K31/7048;A61K31/7064;A61K38/00;A61K47/48;A61P13/08;A61P35/00;C07K7/06;C07K7/08;C07K14/47 主分类号 A61K31/337
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