CHEMICAL COMPOUNDS

摘要

Certain novel imidazole derivatives N-substituted by a vinyl group itself carrying a mevalonic acid derivative or corresponding lactone are inhibitors of HMG-CoA reductase and are useful for lowering blood plasma cholesterol levels. The compounds are of general formula (I): (I) in which one of the groups R1 and R2 represents a C1-6alkyl group optionally substituted by one to three halogen atoms and the other represents a phenyl ring optionally substituted by one to five substituents selected from halogen atoms and hydroxyl, C1-3alkyl, C1-3alkoxy, S(O)nC1-3alkyl, (CH2)mNRaRb, (CH2)mNRcCORd and trifluoromethyl groups; R3 represents a phenyl ring optionally substituted by one to five substituents selected from halogen atoms and hydroxyl, C1-3alkyl, C1-3alkoxy, S(O)nC1-3alkyl, (CH2)mNRaRb, (CH2)mNRcCORd and trifluoromethyl groups; with the proviso that at least one of the groups R1, R2 and R3 contains an S(O)nC1-3alkyl, (CH2)mNRaRb or (CH2)mNRcCORd substituent; X represents -CH=CH-; Z represents (a) (or) (b) and physiologically acceptable solvates, physiologically acceptable acid addition salts thereof when R4 represents hydrogen or a physiologically acceptable and metabolically labile carboxyl protecting group when Z is (a), and quaternary ammonium derivatives thereof.