发明名称 |
cDNA corresponding to the antigenome of nonsegmented negative strand RNA viruses, and process for the production of such viruses encoding additional antigenically active proteins |
摘要 |
<p>The present invention relates, in general, to a methodology for the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids in somatic gene therapy applications. The invention also relates to cDNA molecules suitable as tools in this methodology and to helper cell lines allowing the direct rescue of such viruses. Measles virus (MV) is used as a model for other representatives of the Mononegavirales, in particular the family Paramyxoviridae. <IMAGE></p> |
申请公布号 |
AU721202(B2) |
申请公布日期 |
2000.06.29 |
申请号 |
AU19960068208 |
申请日期 |
1996.08.09 |
申请人 |
SCHWEIZ. SERUM- & IMPFINSTITUT BERN |
发明人 |
MARTIN A. BILLETER;PIUS SPIELHOFER;KARIN KALIN;FRANK RADECKE;HENRIETTE SCHNEIDER |
分类号 |
A01N65/00;A61K31/70;A61K39/00;A61K39/155;A61K39/165;A61K48/00;C07K14/12;C07K14/145;C12N7/00;C12N7/01;C12N7/02;C12N9/00;C12N15/45;C12N15/62;C12N15/86;C12Q1/68;(IPC1-7):C12N15/86 |
主分类号 |
A01N65/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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