RETINOID AGONISTS

摘要

Compounds represented by the general formula (I) or salts thereof, having an ability to potentiate the physiological activities of retinoic acid or retinoids: (I) [wherein R<1> is hydrogen or C1-6 alkyl; R<2> and R<3> are each hydrogen, C1-6 alkyl, or the like; R<4>, R<5>, and R<6> are each hydrogen, halogeno, C1-6 alkyl, or the like; Y is phenylene or pyridinediyl; X is S- or N(R<7>)- (wherein R<7> is hydrogen or C1-6 alkyl); and Z is C-R<8> (wherein R<8> is hydrogen, halogeno, or the like) or N], mor e specifically, compounds represented by the general formula (I) or salts thereof [wherein (1) Z is N, or (2) R<1> is hydrogen or C1-6 alkyl; R<2> and R<3> together with the ring-constituent carbon atoms to which they are bonded form a six-membered ring bearing one or more C1-4 alkyl groups; R<4>, R<5>, and R<6> are each hydrogen; Y is pyridinediyl; X is S-; and Z is CH].