发明名称 |
TNF binding ligands and antibodies |
摘要 |
Antibodies to tumor necrosis factor receptors (TNF-Rs) are disclosed together with methods of producing them. The antibodies are preferably those which inhibit the cytotoxic effect of TNF but not its binding to the TNF-Rs. Most preferably, the antibodies bind to an extracellular domain of the C-terminal cysteine loop of the p75 TNF receptor, which loop consists of the amino acid sequence Cys-185 to Thr-201 of SEQ ID NO:3.
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申请公布号 |
US2002111462(A1) |
申请公布日期 |
2002.08.15 |
申请号 |
US20010800908 |
申请日期 |
2001.03.08 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO., LTD. |
发明人 |
WALLACH DAVID;BIGDA JACEK;BELETSKY IGOR;METT IGOR;ENGELMANN HARTMUT |
分类号 |
A61K38/00;C07K14/715;C07K16/28;C12N15/12;C12N15/13;(IPC1-7):C07K14/705;C12P21/02;C07H21/04;C12N5/06 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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