发明名称 PYRIDINO[2,3-D]PYRIMIDINE DERIVATIVES AS SELECTIVE KDR AND FGFR INHIBITORS
摘要 Disclosed are novel dihydropridinone compounds of the formula (I) wherein Ar, Ar' and R1 are as defined in the description, that are selective inhibitors of both KDR and FGFR kinases. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon lung and prostate tumors. Also, disclosed are pharmaceutical compositions containing these compounds and their preparation.
申请公布号 KR20050088202(A) 申请公布日期 2005.09.02
申请号 KR20057011681 申请日期 2005.06.20
申请人 F. HOFFMANN-LA ROCHE AG 发明人 LIU JIN JUN;LUK KIN CHUN
分类号 A61P35/00;C07D471/04;(IPC1-7):C07D471/04 主分类号 A61P35/00
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