| 摘要 |
Title compds. (I; Z1, Z2, Z3=one means S the others CH; R1, R2=H, C1-5 alkyl, phenyl, halogen) used as preventive of thrombosis, were prepd. from IV(R3=alkyl) with NH3 Reduction of II(X1, X2=Cl, Br) with alkylmetal borohydride to form the III and IV was formed by the reaction of III with α-haloacetic acid ester. Thus, reduction of 4.66g 2, 4-dichloro-5, 6-dimethylthieno(2, 3-d) pyrimidine with 2.32g NaBH4 gave 2.05g 2-chloro-5, 6-dimethyl-3, 4-dihydrothieno(2, 3-d) phrimidine. 6g Above Compd. 5.52g α-bromoethyl acetate and 12.5g K2CO3 were reacted under N2 to give 3g 6, 7-dimethyl-1, 2, 3, 5-tetrahydroimidazo[1, 2-a thieno [2, 3-d pyrimidin-2-on.
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