发明名称 SOLUBILIZATION OF PROTEINS FOR PHARMACEUTICAL COMPOSITIONS USING POLYMER CONJUGATION
摘要 <p>A pharmaceutical composition wherein a biologically active conjugated protein which is beta -interferon, interleukin-2, or an immunotoxin is dissolved in an aqueous carrier medium without the presence of a solubilizing agent. The unconjugated protein, which is not water-soluble at pH 6-8 without such solubilizing agent, is selectively conjugated to a water-soluble polymer selected from polyethylene glycol homopolymers or polyoxyethylated polyols.</p>
申请公布号 GR861641(B) 申请公布日期 1986.09.12
申请号 GR19860101641 申请日期 1986.06.25
申请人 CETUS CORPORATION 发明人 KATRE NANDINI;KNAUF JAMES MICHAEL
分类号 A61K38/00;A61K38/20;A61K38/21;A61K47/00;A61K47/42;A61K47/48;C07K1/107;C07K14/55;C07K14/565;C12N9/00 主分类号 A61K38/00
代理机构 代理人
主权项
地址