| 摘要 |
Title BP-6300-A Freeze-Dried Pharmaceutical Compositions of Phenylquinoline Carboxylic Acids Freeze-dried pharmaceutical compositions of antitumor phenylquinoline carboxylic acids, such as 6-fluoro-2-(2'-fluoro-1'-biphenyl-4-yl) 3-methyl-4-quinolinecarboxylic acid, sodium salt, reconstitutable to stable, aqueous, injectable compositions are provided. These compositions use a stabilization system consisting essentially of a bile salt, such as sodium cholate or sodium desoxycholate, and a base or buffer that will provide a pH of about 8.5-11 upon aqueous reconstitution. Glycine is the preferred buffer. |
