发明名称 |
PROSTAGLANDIN-LIPID FORMULATIONS |
摘要 |
PROSTAGLANDIN-LIPID FORMULATIONS A liposome composition and methods for making same are disclosed, such compositions comprise an arachidonic acid metabolite such as a prostaglandin, preferably prostaglandin R1, a lipid and a drying protectant such as a saccharide. The liposomes may be loaded with prostaglandin passively, or using a transmembrane concentration gradient, preferably using a transmembrane pH gradient. Using this transmembrane loading technique, trapping efficiencies of 50% to 100% are achieved, and the release rate of the prostaglandin from the liposomes is reduced The liposome size is maintained after lypophilization and reconstruction. |
申请公布号 |
CA1323838(C) |
申请公布日期 |
1993.11.02 |
申请号 |
CA19880567474 |
申请日期 |
1988.05.20 |
申请人 |
LIPOSOME COMPANY, INC. (THE) |
发明人 |
LENK, ROBERT P.;TOMSHO, MICHELLE L.;SUDDITH, ROBERT L.;KLIMCHAK, ROBERT J. |
分类号 |
A61K9/127;A61K31/557;A61K31/5575;(IPC1-7):A61K31/557 |
主分类号 |
A61K9/127 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|