DIHYDROPYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION THEREOF

摘要

A dihydropyridine derivative of a formula: <IMG> ¢wherein R1, R2 and R3 are the same or different, and each is alkyl, cycloalkyl or alkoxyalkyl; R4 and R5 are the same or different, and each is hydrogen atom, halogen, nitro, halogenated alkyl, alkylsulfonyl, halogenated alkoxy, alkylsulfinyl, alkyl, cycloalkyl, alkoxy, cyano, alkoxycarbonyl or alkylthio (wherein both of R4 and R5 are not hydrogen atoms at the same time); X is a group represented by vinylene or azomethine; A is alkylene; and B is -N(R6)2 or <IMG> (wherein R6 and R7 are independently hydrogen atom, alkyl, cycloalkyl, aralkyl, aryl or pyridyl, Ar is aryl or pyridyl and n is an integer of 0 to 2)!,or an acid addition salt thereof, has a calcium, blocking action, an antihypertensive action, a platelet aggregation-inhibiting action and a phasphodiesterase-inhibiting action and is useful as medicine.