INOSITOL POLYPHOSPHATE DERIVATIVES AND METHODS OF USING SAME
摘要
The present invention provides compositions that are cell permeable antagonists of inositol polyphosphates. In addition, the invention provides methods for enhancing chloride ion secretion from a cell by contacting the cells with cell permeable antagonists of inositol polyphosphates. The invention also provides methods for enhancing chloride ion secretion in an individual by administering cell permeable antagonists of inositol polyphosphates to the individual. The invention additionally provides methods for alleviating a sign or symptom associated with cystic fibrosis in an individual by administering a cell permeable antagonist of inositol polyphosphates to the individual. The invention also provides compositions that are cell permeable agonists of inositol polyphosphates. In addition, the invention provides methods for decreasing chloride ion secretion from a cell by contacting the cell with cell permeable agonists of inositol polyphosphates. The invention also provides methods for decreasing chloride ion secretion in an individual by administering cell permeable agonists of inositol polyphosphates to the individual. The invention additionally provides methods for alleviating a sign or symptom associated with secretory diarrhea in an individual by administering cell permeable agonists of inositol polyphosphates to the individual.
申请公布号
CA2267348(A1)
申请公布日期
1998.03.26
申请号
CA19972267348
申请日期
1997.09.19
申请人
UNIVERSITY OF CALIFORNIA, SAN DIEGO;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;INOLOGIC, INC.
发明人
RUDOLF, MARCO;TRAYNOR-KAPLAN, ALEXIS;STADLER, CHRISTOPH;SCHULTZ, CARSTEN;ROEMER, STEFAN