NOVEL SUBSTITUTED PURINYL DERIVATIVES HAVING IMMUNOMODULATING ACTIVITY, AND PHARMACEUTICALS CONTAINING THEM AS ACTIVE AGENT

摘要

The present invention comprises a compound of formula I: R1 of Formula I is substituted amino represented by formula NR5R6 wherein R5 and R6 are independently selected from the group consisting of hydrogen, C1-4 alkyl, and unsubstituted amino with the proviso that R5 and R6 are not both hydrogen, and further that R5 and R6 are not both amino. R2 and R3 of Formula I are independently selected from the group consisting of hydrogen; C1-4 alkyl; amino; substituted or unsubstituted thiol; and halogen. Moreover, R4 of Formula I is represented by the formula R12-X12 wherein R12 is a saturated or unsaturated linear hydrocarbon chain of 5-20 carbons optionally containing one or more interruptions within the chain by a heteroatom, and optionally substituted with one or more =O, or =S. Finally, X12 is selected from the group consisting of hydroxy, an aminoalkyl group, and a known amino acid bound by its alpha -amino group.