| 发明名称 |
IL-15 AND IL-15RAPLHA SUSHI DOMAIN BASED MODULOKINES |
| 摘要 |
The present invention relates to an immunocytokine comprising (a) a conjugate, and (b) an immunomodulatory antibody or a fragment thereof directly or indirectly linked by covalence to said conjugate, wherein said conjugate comprises (i) a polypeptide comprising the amino acid sequence of the interleukin 15 or derivatives thereof, and a polypeptide comprising the amino acid sequence of the sushi domain of the IL-15Rα or derivatives thereof; and uses thereof. |
| 申请公布号 |
US2016175459(A1) |
申请公布日期 |
2016.06.23 |
| 申请号 |
US201414910475 |
申请日期 |
2014.08.08 |
| 申请人 |
CYTUNE PHARMA ;UNIVERSITE PARIS DESCARTES ;ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS |
发明人 |
GEY Alain;TARTOUR Eric;BECHARD David |
| 分类号 |
A61K47/48;C07K14/54;A61K38/20;C07K16/28 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An immunocytokine comprising:
a) a conjugate, and b) an immunomodulatory antibody or a fragment thereof directly or indirectly linked by covalence to said conjugate,wherein said conjugate comprises:
(i) a polypeptide comprising the amino acid sequence of the interleukin 15 or derivatives thereof, and (ii) a polypeptide comprising the amino acid sequence of the sushi domain of the IL-15Rα or derivatives thereof. |
| 地址 |
Nantes FR |
