| 发明名称 |
VACCINE COMPOSITION |
| 摘要 |
The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are characterized by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS. |
| 申请公布号 |
US2016175423(A1) |
申请公布日期 |
2016.06.23 |
| 申请号 |
US201615058493 |
申请日期 |
2016.03.02 |
| 申请人 |
GlaxoSmithKline Biologicals S.A. |
发明人 |
BERTHET Francois-Xavier Jacques;DALEMANS Wilfried LJ;DENOEL Philippe;THONNARD Joelle;FERON Christiane;POOLMAN Jan;THIRY Georges;VOET Pierre;LOBET Yves;DEQUESNE Guy |
| 分类号 |
A61K39/095;C12N15/10;C12N15/74 |
主分类号 |
A61K39/095 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for producing a genetically-engineered bleb preparation from a Neisserial bacterial strain comprising modified lipid A portion of bacterial LPS within the bleb preparation, comprising the steps of:
(a) identifying a msbB gene involved in rendering the lipid A portion of LPS toxic, (b) engineering a bacterial strain so as to reduce or switch off expression of said gene, and (c) making blebs from said strain. |
| 地址 |
Rixensart BE |
