Coumarin derivatives for cancer therapy

摘要

The disclosure provides methods and compositions for treating and preventing cancer using 6-substituted coumarin derivatives. The coumarin derivatives of the disclosure have substituents at the 6-position with five carbon atoms or greater. The coumarin derivatives may be further substituted and may be 3,4-dihydrocoumarins. In preferred embodiments, the coumarin derivatives of the disclosure are used to treat pancreatic cancer.

主权项

1. A method for inhibiting proliferation or survival of a hyperproliferative cell, wherein the hyperproliferative cell is a pancreatic cancer cell, comprising contacting the cell with a coumarin derivative, wherein the coumarin derivative is substituted with at least one substituent at the 6-position,
wherein the coumarin derivative is selected from: