| 摘要 |
<p>L-alpha-Hydrazine-beta-phenylpropionic acid cpds. - decarboxylase-inhibitors Cpds. of general formula (I): R1 and R2 = H, hydroxyl, alkoxy (max. C6), phenyloxy or benzyloxy; R3 and R4 = H or alkyl (max. C6); R5 = H, a metal atom or alkyl (max. C6). (I) are decarboxylase-inhibitors in mammals. They do not pass the blood-brain barrier and may be used together with L-Dopa in the treatment of Parkinsonism causing very much reduced doses of L-Dopa. They may also be used in the treatment of diseases of the large intestine, where they inhibit the formation of serotonin and contg. the occurrence of diarrhoea. (I) do not only inhibit dioxyphenylalaninedecarboxylase but also histidine-decarboxylase and may therefore be useful as histamins. (I) do not have other physiological activity. Prepd. by splitting a racemate or other mixture of the D- and L-isomers of (I) or the L-isomer of a cpd. of general formula (II) is reacted with a halogenating agent and a base, or decomposed photolytically to give (I).</p> |
