发明名称 |
HUMAN COMPLEMENTARITY DETERMINING REGION (CDR) - GRAFTED ANTIBODY TO GANGLIOSIDE GM2 |
摘要 |
A human CDR-grafted antibody which specifically reacts with ganglioside GM2, wherein said antibody comprises CDR 1, CDR 2 and CDR 3 of heavy chain (H chain) variable region (V region) comprising amino acid sequences described in SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3, and CDR 1, CDR 2 and CDR 3 of light chain (L chain) V region comprising amino acid sequences described in SEQ ID NO:4, SEQ ID NO: 5 and SEQ ID NO:6, and wherein at least one of the frameworks (FR) of said H chain and L chain V regions comprises an amino acid sequence selected from common sequences (HMHCS; human most homologous consensus sequence) derived from human antibody subgroups.
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申请公布号 |
CA2226400(A1) |
申请公布日期 |
1998.09.19 |
申请号 |
CA19982226400 |
申请日期 |
1998.03.19 |
申请人 |
KYOWA HAKKO KOGYO CO., LTD. |
发明人 |
HANAI, NOBUO;NAKAMURA, KAZUYASU |
分类号 |
G01N33/53;A61K38/00;A61K39/395;A61P35/00;C07K16/18;C07K16/30;C12N5/00;C12N5/10;C12N15/09;C12N15/13;C12P21/08;C12R1/91;G01N33/531;G01N33/574;G01N33/577;G01N33/92;(IPC1-7):C12N15/13;A61K51/10;C07K16/46;C12N15/62 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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