发明名称 |
Penetration enhancers for transdermal delivery of systemic agents |
摘要 |
This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said systemic agent an effective amount of a membrane penetration enhancer having the structural formula <IMAGE> wherein each X, Y and Z may represent oxygen, sulfur or two hydrogen atoms, provided however that, when Z represents two hydrogen atoms, both X and Y represent oxygen or sulfur and when Z represents oxygen or sulfur at least one of X and Y must represent oxygen or sulfur; m is 2-6; R' is H or a lower alkyl group having 1-4 carbon atoms; n is 0-16 and R is -CH3, <IMAGE> wherein R'' is H or halogen.
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申请公布号 |
US4886783(A) |
申请公布日期 |
1989.12.12 |
申请号 |
US19880233551 |
申请日期 |
1988.08.17 |
申请人 |
NELSON RESEARCH & DEVELOPMENT CO. |
发明人 |
MINASKANIAN, GEVORK;PECK, JAMES V. |
分类号 |
A01N25/02;A01N37/32;A01N43/46;A61K47/22;C05G3/00 |
主分类号 |
A01N25/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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