Antimicrobial quinolonyl esters

摘要

Antimicrobial quinolnyl lactam esters comprising a lactam-containing moiety linked, by an ester group, to the 3-carboxy group of a quinolone moiety. These compounds are of the formula: <IMAGE> wherein (1) R3, R4, and R5, together with bonds "a" and "b", form certain lactam-containing moieties similar to those known in the art to have antimicrobial activity; and (2) A, R6, R7, and R8 form any of a variety of quinolone or napthyridine structures similar to those known in the art to have antimicrobial activity.