| 发明名称 |
OB PROTEIN DERIVATIVES HAVING PROLONGED HALF-LIFE |
| 摘要 |
The present invention concerns long half-life derivative of the obesity protein OB. The invention specifically concerns OB protein-immunoglobulin chimeras and polyethylene glycol (PEG)-OB derivatives, which have extended half-life as compared to the corresponding native OB proteins. The invention further relates to methods for appetite and/or weight reduction and for treating other physiological conditions by using the long half-life derivatives of OB.
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| 申请公布号 |
CA2238307(A1) |
申请公布日期 |
1997.07.10 |
| 申请号 |
CA19962238307 |
申请日期 |
1996.12.19 |
| 申请人 |
GENENTECH, INC. |
发明人 |
DE SAUVAGE, FREDERIC J.;LEVIN, NANCY;VANDLEN, RICHARD L. |
| 分类号 |
C12N15/09;A61K31/00;A61K38/00;A61K38/22;A61K39/395;A61P3/00;A61P3/04;A61P3/10;A61P5/50;C07K14/575;C07K14/705;C07K16/18;C07K19/00;C12N1/21;C12N5/10;C12N15/16;C12N15/70;C12P21/02;(IPC1-7):C12N15/62;C07K17/08;C12N15/13;A61K47/48 |
主分类号 |
C12N15/09 |
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