| 摘要 |
<p>Process of preparation of valacyclovir (I), wherein derivative (IV) of acyclovir (I), in which the OH group of acyclovir at the omega position has been replaced by a good leaving group Z, is reacted with an alkaline salt of L-valine (V), to give intermediate (VI), which is successively hydrolyzed in an acid medium to give the corresponding salified valacyclovir (I-A), which may be optionally transformed into valacyclovir (I).</p> |
